Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus
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منابع مشابه
Is Hippocampus Susceptible to Antinociceptive Tolerance to NSAIDs Like the Periaqueductal Grey?
Emotional distress is the most undesirable feature of painful experience. Numerous studies have demonstrated the important role of the limbic system in the affective-motivational component of pain. The purpose of this paper was to examine whether microinjection of nonsteroidal anti-inflammatory drugs (NSAIDs), Clodifen, Ketorolac, and Xefocam, into the dorsal hippocampus (DH) leads to the devel...
متن کاملRetracted: Is Hippocampus Susceptible to Antinociceptive Tolerance to NSAIDs Like the Periaqueductal Grey?
[This retracts the article DOI: 10.1155/2014/654578.].
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In the present study, the effects of intra-hippocampal microinjections of morphine (an opioid agonist) and naloxone (an opioid antagonist) were investigated in the formalin-induced orofacial pain in rats. Orofacial pain was induced by subcutaneous injection of formalin (1 %, 50 μl) in the upper lip region and the time spent of face rubbing was measured in 3-min blocks for 45 min. Formalin induc...
متن کاملAntinociceptive tolerance to NSAIDs in the agranular insular cortex is mediated by opioid mechanism
Several lines of investigations have shown that in some brain areas, in particular, in the midbrain periaqueductal gray matter, rostral ventromedial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of nonsteroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. The agranular insular cortex (AIC) i...
متن کاملThe central nucleus of amygdala is involved in tolerance to the antinociceptive effect of NSAIDs
Aim: Repeated microinjections of non-opioid analgesics into the midbrain periaqueductal gray matter and rostral ventro-medial medulla induce antinociception with development of tolerance. Antinociception following systemic administration of non-steroidal anti-inflammatory drugs (N SAIDs) also exhibit tolerance. Presently our aim was to investigate the development of tolerance to the antinocicep...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2014
ISSN: 2050-6511
DOI: 10.1186/2050-6511-15-10